Trinnpris angis for ikke-patenterte legemidler, hvor det foreligger generisk konkurranse mellom legemidler som Direktoratet for medisinske produkter har vurdert som likeverdige.
carbamazepine will minimize the level or impact of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
Hold a summary of your remedies along with you, and share this details together with your physician and pharmacist. Check out with the well being treatment Expert or doctor For added health-related guidance, or When you've got overall health queries, concerns or for more information relating to this medication.
crizotinib raises amounts of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Dose reduction could possibly be wanted for coadministered prescription drugs which have been predominantly metabolized by CYP3A.
Within this review we summarize and explore previously printed research on modafinil’s neural, cytoprotective, and cognitive effects, and we suggest attainable Major biochemical targets that could underlie the consequences of modafinil observed in these studies. We also advise neurocognitive mechanisms liable for modafinil’s cognitive enhancing outcomes and its therapeutic possible from the remedy of stimulant dependancy.
Edgar and Seidel (1997) investigated the results of modafinil on snooze-wake EEG and locomotor action in Reside rats in comparison with the consequences of methamphetamine. They uncovered that modafinil greater locomotor action only somewhat in contrast to methamphetamine which induced profound improves in locomotor exercise.
fosphenytoin will lessen the level or outcome of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Ishizuka et al (2003) measured Mind histamine release employing microdialysis in vivo in rats specified modafinil intraperitoneally, intraventricullarlry, or straight in to the tuberomamillary nucleus (TMN) and found that modafinil had no effect on HA when administered instantly in to the TMN neurons, and had the quickest effect on histamine when presented ip, indicating that modafinil did circuitously focus on the TMN.
The length of the outcome was longest for dextroamphetamine and shortest for caffeine. At earlier mentioned doses, caffeine turned out to acquire by far the most "subjectively documented Uncomfortable side effects", followed by dextroamphetamine. Dextroamphetamine was the sole stimulant that had adverse outcomes on subsequent Restoration snooze. Modafinil didn't clearly show significant, subjectively-reported side-effects nor subsequent recovery sleep in comparison with placebo. The efficiency of those 3 stimulants is arranged in Table one.
tecovirimat will improve the amount or outcome of modafinil by influencing hepatic enzyme CYP2C19 metabolism. Use Warning/Monitor. Tecovirimat is actually a weak inhibitor of CYP2C8 and CYP2C19. Check for adverse outcomes if coadministered with delicate substrates of those enzymes.
Modafinil could be habit-forming. Under no circumstances share modafinil with Yet another human being, Specially someone by using a history of drug abuse or habit. Keep the medication in an area where Other folks can't reach it. Offering or giving freely modafinil is in opposition to the regulation.
Since modafinil’s actions tend to be more qualified and selective, it is believed to provide a “smoother,” a lot less jittery Vitality, have much less severe side effects, and be improved tolerated by using a reduced opportunity for abuse or addiction than amphetamines.[six]
You should not use this medicine For those who have ever had an allergic response or pores and skin rash though taking modafinil or armodafinil (Nuvigil).
Bettendorf et al (1996) employed superior functionality liquid chromatography to check cortical glutamate and GABA levels of sacrificed rats immediately after modafinil-induced paradoxical rest deprivation and non-pharmacological paradoxical slumber deprivation using the System strategy, by which the paralysis of REM snooze read more triggers rats to generate connection with water and awaken. They located that modafinil didn't improve cortical glutamate stages in two or in seven hours of slumber deprivation. Additionally they uncovered that non-pharmacologic sleep deprivation did not raise cortical glutamate in a similar period of time (five several hours), however it did enhance cortical glutamate immediately after twelve and 24 hours (there were no reviews of information gathered from modafinil-dealt with mice just after 12 or 24 hours of sleep deprivation).